Inhibitors of indoleethylamine N-methyltransferase. Derivatives of 3-methyl-2-thiazolidinimine. In vitro, in vivo, and metabolic studies

J Rokach, Y Girard, P Hamel, G Reader…

Index: Rokach; Girard; Hamel; Reader; Rooney; Mandel; Cragoe Jr.; Zacchei Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 773 - 780

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Citation Number: 14

Abstract

A variety of substituent groups has been attached to the exocyclic imine function of 2-imino-3- methylthiazolidine (1) in a search for metabolic precursors of this potent inhibitor of the enzyme indoleethylamine N-methyltransferase (INMT) which would exhibit superior pharmacodynamic properties in animals. It has been determined that chemically stable derivatives of 1 based on succinic, nicotinic, and N-acylated amino acids, although they ...