Helvetica chimica acta

Stereospecific synthesis of carbanucleotides designed for antisense methodology

XF Zhu, F Nydegger, A Gossauer

Index: Zhu, Xue-Feng; Nydegger, Freddy; Gossauer, Albert Helvetica Chimica Acta, 2004 , vol. 87, # 9 p. 2245 - 2265

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Citation Number: 8

Abstract

Abstract A short stereospecific synthesis of the carbocyclic 2′-deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8, 9, 10-trinorborn-5-en-2-one (1) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides.