Cardioselective anti-ischemic ATP-sensitive potassium channel (K ATP) openers: benzopyranyl indoline and indole analogues

S Lee, KY Yi, SK Kim, J Suh, NJ Kim, S Yoo…

Index: Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 459 - 471

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Citation Number: 19

Abstract

This paper describes the design, syntheses, and biological evaluations of novel ATP- sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives. Among those, two enantiomers of indoline-2-carboxylic ethyl esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation> 30 μM). The cardioprotective ...