Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening …

J Xiang, Z Zhang, Y Mu, X Xu, S Guo, Y Liu…

Index: Niphade, Navnath C.; Mali, Anil C.; Pandit, Bhushan S.; Jagtap, Kunal M.; Jadhav, Sanjay A.; Jachak, Madhukar N.; Mathad, Vijayavitthal T. Organic Process Research and Development, 2009 , vol. 13, # 4 p. 792 - 797

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Abstract

... for the discovery of tool compounds and drug leads.(10) However, this method requires robotics ... With this iterative process, we have discovered novel anticancer agents with potent activity and low ... It was noteworthy that sulfone 1w (n = 2) showed a 23-fold increase of cytotoxicity ...