Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo [3.1. 0] hexane-2, 6-dicarboxylates: identification of new potent and selective …

JA Monn, MJ Valli, SM Massey, J Hao…

Index: Henry, Steven S.; Brady, Molly D.; Laird, Dana L. T.; Ruble, J. Craig; Varie, David L.; Monn, James A. Organic Letters, 2012 , vol. 14, # 11 p. 2662 - 2665

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Citation Number: 9

Abstract

As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1 S, 2 S, 5 R, 6 S-2-aminobicyclo [3.1. 0] hexane-2, 6-dicarboxylate (LY354740), a potent and