Synthesis of novel nucleoside 5′-triphosphates and phosphoramidites containing alkyne or amino groups for the postsynthetic functionalization of nucleic acids

SV Vasilyeva, BI Budilkin, DA Konevetz…

Index: Vasilyeva, Svetlana V.; Budilkin, Boris I.; Konevetz, Dmitrii A.; Silnikov, Vladimir N. Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 10 p. 753 - 767

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Citation Number: 14

Abstract

A series of novel nucleoside 5′-triphosphates and phosphoramidites containing alkyne or amino groups for the postsynthetic functionalization of nucleic acids were designed and synthesized. For this purpose, the new 3-aminopropoxypropynyl linker group was used. It contains two alternative functional capabilities: an amino group for the reaction of amino– alkynyl-modified oligonucleotides with corresponding activated esters and an alkyne ...