Direct synthesis of 1, 5-disubstituted-4-magnesio-1, 2, 3-triazoles, revisited

A Krasinski, VV Fokin, KB Sharpless

Index: Krasinski, Antoni; Fokin, Valery V.; Sharpless, K. Barry Organic Letters, 2004 , vol. 6, # 8 p. 1237 - 1240

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Citation Number: 231

Abstract

After revisiting earlier works reporting the regioselective synthesis of 1, 5-disubstituted-1, 2, 3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1, 4, 5- trisubstituted 1, 2, 3-triazoles.