Synthesis and cyclooxygenase-2 inhibiting property of 1, 5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: preparation of sodium salt …

…, A Vanguri, R Mullangi, NVS Rao Mamidi…

Index: Pal, Manojit; Veeramaneni, Venugopal Rao; Padakanti, Srinivas; Nagabelli, Murali; Vanguri, Akhila; Mamnoor, Premkumar; Casturi, Seshagiri Rao; Misra, Parimal; Mullangi, Ramesh; Yeleswarapu, Koteswar Rao Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 3 p. 593 - 601

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Citation Number: 54

Abstract

A series of 1, 5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substitution on the benzenesulfonamide moiety along with an electron-donating group at the 4-position of the 5-aryl ring yielded selectivity as well as potency for COX-2 inhibition in ...