Enamide-Benzyne-[2+ 2] Cycloaddition: Stereoselective Tandem [2+ 2]− Pericyclic Ring-Opening− Intramolecular N-Tethered [4+ 2] Cycloadditions

JB Feltenberger, R Hayashi, Y Tang, ESC Babiash…

Index: Feltenberger, John B.; Hayashi, Ryuji; Tang, Yu; Babiash, Eric S.C.; Hsung, Richard P. Organic Letters, 2009 , vol. 11, # 16 p. 3666 - 3669

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Citation Number: 74

Abstract

Benzyne-[2+ 2] cycloadditions with enamides are described. This effort led to the development of a highly stereoselective tandem [2+ 2] cycloaddition− pericyclic ring- opening− intramolecular-N-tethered-[4+ 2] cycloaddition for rapid assembly of nitrogen heterocycles.