Acetylenic carbamates. III. The N-cycloaliphatic derivatives

RD Dillard, GA Poore, NR Easton…

Index: Dillard,R.D. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1155 - 1158

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Citation Number: 11

Abstract

The series of acetylenic carbamates was extended with emphasis 011 the N-cycloaliphatic derivatives. The N-cycloaliphatics had much less cell culture cytotoxicity and neurotoxicity as determined by intrathecal studies~ II dogs than the NHz compounds, even though their acutcb toxicities were about the same. 11Iost of the N-cycloaliphatic compounds exhibited ant it umor activity.