Synthesis and Application of N??Hydroxylamine Derivatives as Potential Replacements for HOBt

A El??Faham, F Albericio

Index: El-Faham, Ayman; Albericio, Fernando European Journal of Organic Chemistry, 2009 , # 10 p. 1499 - 1501

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Citation Number: 9

Abstract

Abstract Several heterocycles containing N-hydroxylamine were prepared and tested as coupling additives to replace the use of N-hydroxybenzotriazole (HOBt) derivatives. On the basis of our results on coupling yield and racemization-suppressing properties, we propose N-hydroxyindolin-2-one and 6-chloro-N-hydroxy-2-phenylbenzimidazole as suitable substitutes for HOBt.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany ...