Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform
B Desai, K Dixon, E Farrant, Q Feng…
Index: Journal of Medicinal Chemistry, , vol. 56, # 7 p. 3033 - 3047
Full Text: HTML
Citation Number: 29
Abstract
... Journal of Medicinal Chemistry. ... Some chemistry development time is required to ensure that analogues can be made in a microfluidic reactor, and the efficient resolution of synthetic chemistry challenges is critical to the success of this approach. ...
Related Articles:
Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant†
[Organic Process Research and Development, , vol. 12, # 6 p. 1146 - 1155]
[Bioorganic and Medicinal Chemistry, , vol. 18, # 20 p. 7150 - 7163]
Small-molecule inducer of β cell proliferation identified by high-throughput screening
[Journal of the American Chemical Society, , vol. 135, # 5 p. 1669 - 1672]
Small-molecule inducer of β cell proliferation identified by high-throughput screening
[Journal of the American Chemical Society, , vol. 135, # 5 p. 1669 - 1672]
Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant†
[Organic Process Research and Development, , vol. 12, # 6 p. 1146 - 1155]