Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl) furfural

F Chang, S Dutta, JJ Becnel, AS Estep…

Index: Chang, Fei; Dutta, Saikat; Becnel, James J.; Estep, Alden S.; Mascal, Mark Journal of Agricultural and Food Chemistry, 2014 , vol. 62, # 2 p. 476 - 480

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Citation Number: 11

Abstract

Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl) furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes aegypti indicates promising insecticidal activities.