γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

…, IKH Leung, TDW Claridge, CJ Schofield

Index: Henry, Luc; Leung, Ivanhoe K.H.; Claridge, Timothy D.W.; Schofield, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 4975 - 4978

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Citation Number: 7

Abstract

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe (II)-dependent oxygenase that catalyses the final step of l-carnitine biosynthesis in animals. BBOX catalyses the oxidation of 3-(2, 2, 2-trimethylhydrazinium) propionate (THP), a clinically used BBOX inhibitor, to form multiple products including 3-amino-4-(methyamino) butanoic acid (AMBA), which is proposed to be formed via a Stevens type rearrangement mechanism. We report ...