Synthesis and pharmacological evaluation of ether and related analogs of. DELTA. 8-,. DELTA. 9-, and. DELTA. 9, 11-tetrahydrocannabinol
DR Compton, WR Prescott Jr, BR Martin…
Index: Compton; Prescott Jr.; Martin; Siegel; Gordon; Razdan Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3310 - 3316
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Citation Number: 20
Abstract
The primary goal of this research was to synthesize a series of ether analogues of the cannabinoid drug class and to evaluate their agonist and antagonist pharmacological properties in either the mouse or the rat. Agonist and antagonist activity was evaluated in mice using a multiple-evaluation procedure (locomotor activity, tail-flick latency, hypothermia, ring immobility) and activity in rats determined in a discriminative stimulus ...
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