Bioorganic Chemistry

Catalytic properties of carbonyl reductase from rabbit kidney for acetohexamide and its analogs

Y Imamura, T Higuchi, M Otagiri, S Nagumo…

Index: Imamura, Yorishige; Higuchi, Toshiyuki; Otagiri, Masaki; Nagumo, Shinji; Akita, Hiroyuki Bioorganic Chemistry, 1994 , vol. 22, # 4 p. 387 - 394

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Citation Number: 3

Abstract

Abstract Analogs submitted by ethyl, n-propyl, n-butyl, and isopropyl groups instead of methyl group adjacent to a ketone group of acetohexamide were synthesized and the structural requirements of carbonyl reductase from rabbit kidney for these analogs were kinetically examined. The hydrophobicities in straight-chain alkyl groups of acetohexamide analogs were found to play an important role in the catalytic activity and substrate-binding ...