Efficient synthesis of vitamin E intermediate by lipase-catalyzed regioselective transesterification

…, XF Fu, Z Wang, XJ Yu, YJ Zhang, JY Zheng

Index: Wei, Chun; Fu, Xian-Feng; Wang, Zhao; Yu, Xin-Jun; Zhang, Yin-Jun; Zheng, Jian-Yong Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 106, p. 90 - 94

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Citation Number: 4

Abstract

Abstract Trimethylhydroquinone-1-monoacetate (TMHQ-1-MA) is a valuable synthetic intermediate for vitamin E acetate. Immobilized Lipozyme RM IM from Mucor miehei was shown to be the best biocatalyst for the production of TMHQ-1-MA through regioselective transesterification between trimethylhydroquinone diacetate (TMHQ-DA) and alcohol. The effects of lipase-catalyzed reaction conditions including solvent, acyl receptor, substrate ...