Oxidative reactions of azines

…, IA Bekro, SA Soldatova, E Glover, A Temesgen…

Index: Soldatenkov; Bekro; Soldatova; Glover; Temesgen; Kuleshova; Khrustalev; Sergeeva Russian Chemical Bulletin, 1997 , vol. 46, # 11 p. 1916 - 1919

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Abstract

Abstract Oxidative coupling of 1-alkyl (benzyl)-4-(γ-pyridyl)-1, 2, 5, 6-tetrahydropyridines with acetone in the presence of KMnO 4 follows two pathways and yields both 1-R-2- (acetylmethylene) tetrahydropyridines and 1-R-3, 4-dihydroxypiperidin-2-ones. When acetonitrile is used instead of acetone, the reaction under similar conditions occurs as selective ketodihydroxylation of the starting piperideines yielding 1-R-3, 4-dihydroxy-4-(γ- ...