Substituted 3??Amido and 3??Amidoalkylbenzopyran Derivatives: Synthesis and Pharmacological Activity as Melatonin Ligands

…, B GUARDIOLA??LEMAITRE, HE Howell…

Index: Viaud; Mamai; Guerin; Bennejean; Renard; Delagrange; Guardiola-Lemaitre; Howell; Guillaumet Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 1 p. 47 - 56

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Citation Number: 7

Abstract

Abstract A novel series of melatonin analogues based on the benzopyran nucleus is described. These compounds are prepared in several steps from substituted 2- hydroxybenzaldehydes. Some of these derivatives competitively inhibit 2-['251] iodomelatonin binding to chicken brain and ovine pars tuberalis membranes although with reduced affinity compared with melatonin.