Synthesis and NK 1/NK 2 receptor activity of substituted-4 (Z)-(methoxyimino) pentyl-1-piperazines

…, JF Lee, JC Anthes, NY Shih, JJ Piwinski

Index: Ting, Pauline C.; Lee, Joe F.; Anthes, John C.; Shih, Neng-Yang; Piwinski, John J. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2333 - 2335

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Citation Number: 20

Abstract

A series of 5-[(3, 5-bis (trifluoromethyl) phenyl) methoxy]-3-(3, 4-dichlorophenyl)-4 (Z)- (methoxyimino) pentyl-1-piperazines was prepared and their affinity for the NK1 and NK2 receptors investigated. Compounds 7f, 10o, 10r, and 10s were found to be our most potent inhibitors.