Direct 1, 4-difunctionalization of isoquinoline

F Louërat, Y Fort, V Mamane

Index: Louerat, Frederic; Fort, Yves; Mamane, Victor Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5716 - 5718

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Citation Number: 13

Abstract

The synthesis of 1, 4-disubstituted isoquinoline derivatives was achieved in one step starting from isoquinoline. The process involved a nucleophilic addition in 1-position followed by an electrophilic trapping in 4-position. Interesting features were noted when C2Cl6 was used as the electrophile since different compounds could be isolated selectively only by adjusting the reaction parameters.