A simple one-pot synthesis of nitriles from alcohols

F Camps, V Gasol, A Guerrero

Index: Camps, F.; Gasol, V.; Guerrero, A. Synthetic Communications, 1988 , vol. 18, # 4 p. 445 - 452

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Citation Number: 22

Abstract

Transformation of alcohols into nitriles is often an important process in organic synthesis since it allows direct homologation of the carbon chain of a variety of substrates. The classical methods to achieve the conversion usually involve a two-step sequence: transformation of the alcohol into the corresponding sulfonate ester or halide followed by nucleophilic substitution by cyanide! This latter process is often accompanied by the undesired formation of olefins. ...