Catalytic enantioselective silylation of acyclic and cyclic triols: application to total syntheses of cleroindicins D, F, and C

Z You, AH Hoveyda, ML Snapper

Index: You, Zhen; Hoveyda, Amir H.; Snapper, Marc L. Angewandte Chemie - International Edition, 2009 , vol. 48, # 3 p. 547 - 550

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Citation Number: 58

Abstract

Catalysts that promote site-selective modification of polyfunctional molecules can be of significant utility in selective chemical synthesis.[1] Of particular importance are chiral catalysts that initiate enantioselective functionalization of polyoxygenated molecules [2]— entities commonly found among biologically active agents. Herein, we present methods for the enantioselective silylations [3] of acyclic and cyclic 1, 2, 3-triols [Eq.(1)]; the ...