Molecular iodine: a green and inclusive catalyst for the synthesis of highly functionalized 1, 3, 5-trisubstituted pyrazoles in aqueous medium
P Rai, M Srivastava, J Singh, J Singh
Index: Rai, Pratibha; Srivastava, Madhulika; Singh, Jagdamba; Singh, Jaya RSC Advances, 2014 , vol. 4, # 2 p. 779 - 783
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Citation Number: 7
Abstract
A library of 1, 3, 5-trisubstituted pyrazoles was synthesized in excellent yields from the reaction of aldehyde, phenylhydrazine and alkynes in the presence of iodine via an eco- friendly, simple process performed in aqueous medium. This single pot transformation generates new CN, C–C, C–N bonds and proceeds by a domino reaction involving the formation of Schiff base, Mannich addition and finally intramolecular cyclisation.
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