Synthesis and biological activity of acyclic analogs of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolic acid
…, LS Gossett, JF Worzalla, SM Rinzel…
Index: Shih, Chuan; Gossett, Lynn S.; Worzalla, John F.; Rinzel, Sharon M.; Grindey, Gerald B.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1109 - 1116
Full Text: HTML
Citation Number: 37
Abstract
The synthesis and biological evaluation of a number of analogues of N-[4 [4 (2, 4-diamino-l, 6-dihydro-6-0~ 0-5-py-rimidyl) butyl] be~ yl]-~ glutamic acid (2)(% DM-DDATHF), an acyclic modification of the novel folate antimetabolite 5, 10-dideazatetrahydrofolic acid (DDATHF), are described. The synthetic procedure utilized previously for the synthesis of 2, lS, and 16 was extended to the preparation of analoguea modified in the benzoyl region with ...
Related Articles:
[Apperloo, Joke J.; Janssen, Rene A.J.; Malenfant, Patrick R.L.; Groenendaal, Lambertus; Frechet, Jean M.J. Journal of the American Chemical Society, 2000 , vol. 122, # 29 p. 7042 - 7051]
[Archiv der Pharmazie, , vol. 331, # 12 p. 405 - 411]
[Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478]
[Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1109 - 1116]
Microwave??assisted Synthesis of Difuran and Furan??Thiophene via Suzuki Coupling
[Journal of the Chinese Chemical Society, , vol. 52, # 5 p. 849 - 852]