Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor …

M Gao, D Kong, A Clearfield, QH Zheng

Index: Gao, Mingzhang; Kong, Deyuan; Clearfield, Abraham; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2229 - 2233

Full Text: HTML

Citation Number: 29

Abstract

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6, 7-dimethoxy-1, 2, 3, 4- tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4′-chlorophenyl)-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline ...