Enantioselective Retention of 4??Aryl??1, 4??dihydropyridine Calcium??Channel Blockers on Human Serum Albumin and α1??Acid Glycoprotein HPLC Columns: …

…, F Quaglia, MT Quercia, MI La Rotonda

Index: Barbato, Francesco; Quaglia, Fabiana; Quercia, Maria Tiziana; La Rotonda, Maria Immacolata Helvetica Chimica Acta, 2000 , vol. 83, # 4 p. 767 - 776

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Citation Number: 21

Abstract

Abstract The enantioselective retention of eight 4-aryl-1, 4-dihydropyridine (DHP) calcium- channel blockers on HPLC stationary phases supporting human serum albumin (HSA) or α 1-acid glycoprotein (AGP) was investigated. All chiral neutral DHPs were resolved on the AGP column, whereas, on the HSA column, only isradipine showed a split chromatographic peak. Analyses performed on AGP with eluents containing dimethyloctylamine (DMOA) as ...