Efficient Synthesis of Phosphono??and Phosphinoxidomethylated N??Heterocycles under Solvent??Free Microwave Conditions

…, I Greiner, K Ludányi, G Keglevich

Index: Prauda, Ibolya; Greiner, Istvan; Ludanyi, Krisztina; Keglevich, Gyoergy Synthetic Communications, 2007 , vol. 37, # 2 p. 317 - 322

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Citation Number: 27

Abstract

Abstract Simple N??heterocycles were converted to N??phosphono??and phosphinoxidomethyl derivatives by a solvent??free microwave??assisted condensation of the heterocycle, paraformaldehyde, and diethylphosphite or diphenylphosphine oxide in a convenient and, in most cases, efficient way. In contrast to an earlier report, imidazole proved to be unreactive in this type of phospha??Mannich reaction.