In vitro efficiency of 9-(N-cinnamoylbutyl) aminoacridines against blood-and liver-stage malaria parasites

…, J Gut, PJ Rosenthal, M Prudêncio, P Gomes

Index: Perez, Bianca; Teixeira, Catia; Gomes, Ana S.; Albuquerque, Ines S.; Gut, Jiri; Rosenthal, Philip J.; Prudencio, Miguel; Gomes, Paula Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 610 - 613

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Citation Number: 11

Abstract

Novel 9-aminoacridine derivatives were synthesized by linking the heteroaromatic core to different cinnamic acids through an aminobutyl chain. The test compounds demonstrated mid-nanomolar in vitro activity against erythrocytic stages of the chloroquine-resistant W2 strain of the human malaria parasite Plasmodium falciparum. Two of the most active derivatives also showed in vitro activity against liver-stage Plasmodium berghei, with ...