Potential antidepressant and anti-inflammatory agents: 4-(2-Propylthio) acetophenone oximes and 4-(2-propylthio) phenylalkanoic acids

…, J Grimová, E Maturová, J Holubek…

Index: Jilek, Jiri; Sindelar, Karel; Grimova, Jaroslava; Maturova, Eva; Holubek, Jiri; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 5 p. 1266 - 1277

Full Text: HTML

Citation Number: 1

Abstract

Abstract 4-(2-Propylthio) acetophenone oxime (IV) was reacted with 2-aminoethyl chloride and 3-dimethylaminopropyl chloride to give the O-(aminoalkyl) oximes V and VI which are analogues of the antidepressant agent fluvoxamine (I). Kindler-Willgerodt reaction of 4-(2- propylthio) acetophenone (III) gave the thiomorpholide VII which was hydrolyzed to the acid IX. Friedel-Crafts reaction of (2-propylthio) benzene with ethoxalyl chloride afforded ethyl ...