Tetrahedron

Synthesis and characterisation of N, N-disubstituted 2-amino-5-acylthiophenes and 2-amino-5-acylthiazoles

A Noack, H Hartmann

Index: Noack, Antje; Hartmann, Horst Tetrahedron, 2002 , vol. 58, # 11 p. 2137 - 2146

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Citation Number: 32

Abstract

Starting from halomethyl-ketones 8 and N, N′-persubstituted thioacrylamides 7 or their 2- aza analogues 11 a series of N, N-disubstituted 2-amino-5-acylthiophenes 10 and 2-amino- 5-acylthiazoles 12, respectively are available. By starting from 1, 3-dichloroacetone and using the same thioacrylamide derivatives 7 and 11N, N-disubstituted 2-amino-5- (chloroacetyl) thiophenes 13 and 2-amino-5-(chloroacetyl) thiazoles 14 as well as N, N′- ...