Tetrahedron letters

Asymmetric synthesis of α, α-disubstituted α-amino acid derivatives using MABR promoted rearrangement

M Matsushita, H Maeda, M Kodama

Index: Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752

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Citation Number: 23

Abstract

An efficient route for the asymmetric synthesis of α, α-disubstituted α-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.