The Journal of Organic Chemistry

Facile cycloalkylation of arylacetonitriles in dimethyl sulfoxide

DE Butler, JC Pollatz

Index: Butler,D.E.; Pollatz,J.C. Journal of Organic Chemistry, 1971 , vol. 36, p. 1308 - 1309

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Citation Number: 27

Abstract

A recent publication on the use of sodium hydroxidedimethyl sulfoxide in the alkylation of phenylacetonitrile'has led us to comment on some of our results using sodium hydride- dimethyl sulfoxide. The a-alkylation reactions of nitriles have been surnrnari~ ed~~~ and the use of sodium hydride in dimethyl sulfoxide has been described by Bl~ omfield.~ We have found that good yields of 1-arylcycloalkanecarbonitriles can be obtained techniques ...