Deprotonation of benzylic ethers using a hindered phosphazene base. A synthesis of benzofurans from ortho-substituted benzaldehydes
…, N Zhang, JG Verkade, M Nagarajan, PB Kisanga
Index: Kraus, George A.; Zhang, Ning; Verkade, John G.; Nagarajan, Muthukaman; Kisanga, Philip B. Organic Letters, 2000 , vol. 2, # 16 p. 2409 - 2410
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Citation Number: 66
Abstract
Many natural products and biologically significant synthetic compounds contain either a benzofuran or a dihydrobenzofuran subunit. 1 As a consequence, a number of preparations of benzofurans have been reported. 2 Recently there has been growing interest in developing general and versatile synthetic methods for the synthesis of benzofuran derivatives because of their activity as modulators of androgen biosynthesis (furano steroids), 3 as inhibitors of 5-lipoxygenase, as ...
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