1, 4-Dihydropicolinic acid derivatives: novel NADH analogues with an altered connectivity pattern

E Gómez, M Miguel, O Jiménez, G de la Rosa…

Index: Gomez, Elena; Miguel, Miriam; Jimenez, Oscar; De La Rosa, Guillermo; Lavilla, Rodolfo Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3513 - 3516

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Citation Number: 9

Abstract

Sodium dithionite reduction of α-substituted N-alkylpyridinium salts (derived from picolinic acid derivatives) afforded the corresponding 1, 4-dihydropyridines with a new substitution pattern, in which the electron-withdrawing group is at the α-position. These compounds promote biomimetic reductions and are hence considered functional NADH analogues.