Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents

…, Z Li, Y Wang, Y Wu, JD Jiang, DW Boykin

Index: Hu, Laixing; Li, Zhuo-rong; Wang, Yue-ming; Wu, Yanbin; Jiang, Jian-Dong; Boykin, David W. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1193 - 1196

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Citation Number: 33

Abstract

A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2, 6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50= 122 and 101nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of ...