Enantioselective construction of quaternary stereocenter through a reissert-type reaction catalyzed by an electronically tuned bifunctional catalyst: Efficient synthesis of …

K Funabashi, H Ratni, M Kanai…

Index: Funabashi; Ratni; Kanai; Shibasaki Journal of the American Chemical Society, 2001 , vol. 123, # 43 p. 10784 - 10785

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Citation Number: 165

Abstract

Catalytic enantioselective construction of chiral quaternary stereocenters is a formidable challenge. 1 For this type of reaction to proceed successfully, catalysts must differentiate between the subtle sterical differences of substituents on a pro-chiral carbon that lacks the remarkably small hydrogen. In addition, catalysts must activate substrates more strongly than in cases of chiral tertiary stereocenter construction, due to higher steric repulsion ...