Application of (2E, 4E)-5-Bromo-2, 4-Pentadienal in Palladium Catalyzed Cross-Coupling: Easy Access to (2E, 4E)-2, 4-Dienals

…, D Castet-Caillabet, Y Ramondenc, G Plé, L Duhamel

Index: Vicart, Nicolas; Castet-Caillabet, Dominique; Ramondenc, Yvan; Ple, Gerard; Duhamel, Lucette Synlett, 1998 , # 4 p. 411 - 412

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Citation Number: 19

Abstract

In the course of our studies about convergent synthesis of polyenic compounds,1 we recently reported the preparation2 of (2E,4E)-5-bromo- 2,5-pentadienal 1. We2 and others3 have taken advantage of the carbonyl group's potential through Wittig, Grignard or oxidation reactions. In this paper, we report the use of 1 as a brominated vinylic entity in palladium catalyzed cross-coupling4 without any protection of the aldehydic function5 (Scheme 1). Their high ...