Tetrahedron letters

Solid phase synthesis of tetrahydro-1, 4-benzodiazepin-2-ones

ND Hone, W Wilson, JC Reader

Index: Hone, Neal D.; Wilson, William; Reader, John C. Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495

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Citation Number: 10

Abstract

The 1,4-benzodiazepine-2,5-dione template has found widespread therapeutic use across a range of disease states. The closely related 1,4-benzodiazepin-2-one nucleus is less utilised yet has demonstrated anticonvulsant, 1 anti-HIV 2 and anti-coagulant 3 activity. We wished to access a diverse range of these compounds for testing throughout a number of discovery programmes. Two solid phase approaches have been disclosed, 4., and and although ...