Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

…, E Debiton, B Aboab, M Prudhomme, P Moreau

Index: Sassatelli, Mathieu; Debiton, Eric; Aboab, Bettina; Prudhomme, Michelle; Moreau, Pascale European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 709 - 716

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Citation Number: 36

Abstract

A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).