Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D 4 receptor antagonist

MA Sanner, TA Chappie, AR Dunaiskis, AF Fliri…

Index: Sanner, Mark A.; Chappie, Thomas A.; Dunaiskis, Audrey R.; Fliri, Anton F.; Desai, Kishor A.; Zorn, Stevin H.; Jackson, Elisa R.; Johnson, Celeste G.; Morrone, Jean M.; Seymour, Patricia A.; Majchrzak, Mark J.; Faraci, W. Stephen; Collins, Judith L.; Duignan, David B.; Di Prete, Cecilia C.; Lee, Jae S.; Trozzi, Angela Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 725 - 730

Full Text: HTML

Citation Number: 37

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D 4 receptor antagonists are reported including CP-293,019 (D 4 K i = 3.4 nM, D 2 K i > 3,310 nM), which also inhibits apomorphine-induced hyperlocomotion in rats after oral dosing. ... A series of potent and ...