Synthesis of. DELTA. 3-1-methylene-1-carbacephems

…, PJ Claes, H Vanderhaeghe

Index: Herdewijn, Piet; Claes, Paul J.; Vanderhaeghe, Hubert Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 661 - 664

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Citation Number: 12

Abstract

The total synthesis of (i)-l-methylene-2, 2-dimethyl-7-amino-l-carbacephem-4-carboxylic acid (1) is described. The reaction scheme was essentially that described by Christensen et al. for the synthesis of (f)-1-carbacephems. In vitro antibacterial activities of the 7- phenoxyacetyl and 7-~-a-phenylglycyl derivatives of 1 were compared with those of 7- (phenoxyacetamido) desacetoxycephalosporanic acid and cefalexin. Derivatives of 1 ...