7-Deazapurine DNA: Oligonucleotides containing 7-substituted 7-deaza-2'-deoxyguanosine and 8-aza-7-deaza-2'-deoxyguanosine

F Seela, N Ramzaeva, G Becher

Index: Seela, Frank; Ramzaeva, Natalya; Becher, Georg Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S258 - S261

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Citation Number: 12

Abstract

The 7-substituents of 7-deazapurines have considerable steric freedom within the major groove of DNA and stabilize the oligonucleotide duplex structure1. Therefore, the 7-position of 7-deazapurines is an ideal position for the fuctionalization of DNA with reporter groups. This investigation reports on the synthesis of 7-substituted 7-deazaguanosine and 7-deaza- 8-azaguanosines, their incorporation into oligonucleotides, and the stability of ...