2, 7-Di-tert-butyl-Fmoc-P-OSu: A new polymer-Supported reagent for the protection of the amino group

R Chinchilla, DJ Dodsworth, C Nájera…

Index: Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen; Soriano, Jose M Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1817 - 1820

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Citation Number: 25

Abstract

The polymer-supported (2, 7-di-tert-butyl-9-fluorenyl) methyl succinimidyl carbonate (Dtb- Fmoc-P-OSu), derived from (2, 7-di-tert-butyl-9-fluorenyl) methyl chloroformate (Fmoc-Cl) and a polymeric N-hydroxysuccinimide (P-HOSu), has been used for the preparation of Dtb- Fmoc-protected amines and amino acids. After the N-protection reaction, the liberated P- HOSu can be recovered and reused. This Dtb-Fmoc-protection improves the solubility of ...