Synthesis

Modular design of pyridine-based acyl-transfer catalysts

I Held, S Xu, H Zipse

Index: Held, Ingmar; Xu, Shangjie; Zipse, Hendrik Synthesis, 2007 , # 8 p. 1185 - 1196

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Citation Number: 31

Abstract

Abstract Derivatives of 3, 4-diaminopyridine have been synthesized and studied as catalysts for acyl-transfer reactions. The design of these catalysts is guided by the stability of their acetyl intermediates as determined through theoretical calculations at the B3LYP/6-311+ G (d, p)//B3LYP/6-31G (d) level of theory. The most promising catalysts have been synthesized through a three-to five-step synthesis starting from 3, 4-diaminopyridine. The catalytic ...