Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles

…, MM Jarosz, K Kajewska-Kania…

Index: Kurpet, Marta K.; Dabrowska, Aleksandra; Jarosz, Malgorzata M.; Kajewska-Kania, Katarzyna; Kuznik, Nikodem; Suwinski, Jerzy W. Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1517 - 1525

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Abstract

Abstract A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3 (5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivatives of 4-nitropyrazole, 2-nitroimidazole, 4 ( ...