Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors

…, XC Zhang, J Zhang, QQ Jiang, WJ Yi, W Zhu…

Index: Xun, Miao-Miao; Zhang, Xue-Chao; Zhang, Ji; Jiang, Qian-Qian; Yi, Wen-Jing; Zhu, Wen; Yu, Xiao-Qi Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1242 - 1250

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Citation Number: 5

Abstract

Non-viral gene vectors play an important role in the development of gene therapy. In this report, different hydrophobic chains were introduced into low molecular weight (LMW) PEI- based biodegradable oligomers to form a series of lipopolymers (LPs), and their structure– activity relationships were studied. Results revealed that the nine polymers can condense plasmid DNA well to form nanoparticles with appropriate sizes (120–250 nm) and positive ...