Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer

…, M Hector, Y Zhuang, RW Hartmann

Index: Wachall, Bertil G.; Hector, Markus; Zhuang, Yan; Hartmann, Rolf W. Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1913 - 1924

Full Text: HTML

Citation Number: 57

Abstract

3-And 4-imidazol-1-yl-methyl substituted biphenyl compounds (named as meta-and para- substituted compounds) were synthesized bearing additional substituents in 3′-/4′- position as inhibitors of P450 17 (17α-hydroxylase-C17, 20-lyase). P450 17 is the key enzyme of androgen biosynthesis. Its inhibition is a novel therapeutic strategy for treatment of prostate cancer (PC). Twenty-nine compounds were synthesized by Ar-Mg-Br, Negishi ...