A new access to efaroxan and its 5-amino derivatives
T Lomberget, R Barret
Index: Lomberget, Thierry; Barret, Roland Tetrahedron Letters, 2008 , vol. 49, # 4 p. 715 - 718
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Citation Number: 8
Abstract
The formal total synthesis of racemic efaroxan, a 2-disubstituted 2, 3-dihydrobenzofuran having interesting therapeutic properties, and the preparation of some 5-amino derivatives were achieved using a convergent approach. The key intermediates of both syntheses were obtained after a [3+ 2] cycloaddition reaction between two easily accessible partners.
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