Palladium??Catalyzed Cross??Coupling of Aryl Chlorides and Tosylates with Hydrazine

RJ Lundgren, M Stradiotto

Index: Lundgren, Rylan J.; Stradiotto, Mark Angewandte Chemie - International Edition, 2010 , vol. 49, # 46 p. 8686 - 8690

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Citation Number: 93

Abstract

Aryl hydrazines are highly valuable intermediates in the synthesis of a number of important nitrogen-containing heterocyclic frameworks such as indoles (through the Fischer indole synthesis),[1] indazoles, aryl pyrazoles, and aryl triazoles.[2] In some cases, hydrazine reacts with haloarenes directly in nucleophilic aromatic substitution reactions; however, such reactions typically occur at high temperatures, and/or only with highly electron-deficient ...